Student engagement is a critical component of e-learning, which became an important focus for most academic institutions during the COVID-19 pandemic. University students' engagement is measured using various scales with different subscales. This study aimed to evaluate the psychometric properties of the Persian version of the University Student Engagement Inventory (P-USEI). A cross-sectional methodology study was conducted among Iranian university students (n = 667) from April to May 2020. After forward-backward translation, the content, and construct validity, and reliability of the scale were assessed. The results obtained from the confirmatory factor analysis confirmed that the P-USEI has three factors: cognitive, emotional, and behaviour. The findings of the study supported the adequate reliability, factorial, convergent, and discriminant validities of P-USEI in a sample of Iranian students. The P-USEI dimensions have predictive value for important academic variables that can be generalized by developing the research through a psychometric evaluation on student engagement.