The purpose of this qualitative case study was to explore how an after-school program that infused Maker education influenced Midwestern U.S. middle school youths' attitudes toward science. The researchers conducted pre- and post-interviews with six students from non-dominant backgrounds as well as the teacher, and also administered attitudinal surveys to the six students at two time points (pre/post). Additionally, the researchers observed the level of student participation by video-recording each after-school session, observed the level of student anxiety by using skin temperature biofeedback, and examined student artifacts. At the end of the program, the researchers administered a program survey to the six students. The findings revealed three themes (fun elements of science, career choice, trial and error). In this study, the after-school program infused with Maker education showed great potential in sustaining the non-dominant youths' positive attitudes toward science. The findings speak to the need for future studies that investigate pedagogy issues in Making after-school programs and also highlight equity issues in the opportunities for non-dominant youth to participate in these programs.