Neonatal Abstinence Syndrome (NAS) is the term used to describe newborn experiences of withdrawal after exposure to opioids or other substances in utero (Kondili & Duryea, 2019). An urgent need exists for trained practitioners to serve children with NAS and their families (e.g., Gregory, 2014; Hancock et al., 2017; Health care Cost and Utilization Project [HCUP], 2019; Patrick et al., 2016). To address this need, three Division of Early Childhood (DEC) of the Council for Exceptional Children Recommended Practices (RPs) can support practitioners' work with families of children with NAS (DEC, 2014): (1) Family-centered practice (DEC RP F1). "Practitioners build trusting and respectful partnerships with families through interactions that are sensitive and responsive to cultural, linguistic, and socio-economic diversity" (DEC, 2014, p. 10); (2) Transition (DEC RP TR2). "Practitioners use a variety of planned and timely strategies with the child and family before, during, and after transitions to support successful adjustment and positive outcomes for both the child and family" (DEC, 2014, p. 16); and (3) Instruction 13 (DEC RP INS13). "Practitioners use coaching or consultation strategies with primary caregivers or other adults to facilitate positive adult-child interactions and instruction intentionally designed to promote child learning and development" (DEC, 2014, p. 13). To support practitioners' services to children with NAS and their families, this article focuses on their interactions with families during the first phase of a child's life, the time from the child's birth to the transition to home. The article includes current information on NAS and describes how each of the related DEC RPs inform best practice strategies for practitioners. It concludes with a list of multiple resources available for practitioners.