The main aim of this paper is to address the increasing need for science-art integration across all levels of education globally. Specifically, the need to identify a signature pedagogy for the Global Science Opera (GSO) that can be used in teaching and learning contexts in formal and non-formal education. This part of the paper draws upon the seminal work of Lee Shulman (2005) to contemplate and propose a signature pedagogy for the GSO. Contemporary ideas from the science-art teaching and learning sources are also used to develop a sound pedagogical foundation for the approach advocated by the GSO. We argue that the development of a signature pedagogy for the GSO provides clarity around the challenge of developing a standard approach to teaching science through art activities. This paper presents the GSO practices that has the potential influence to reshape science teaching and learning process through art.