This article presents an experimental teaching innovation and entrepreneurial training project where first year university students respond in teams to an entrepreneurial challenge with a product or service associated with the UN Sustainable Development Goal. One group of students received complementary training in entrepreneurship. The effect of the project on the motivation and preparation for entrepreneurship was measured through a self-evaluation questionnaire and the evaluation of the project by experts. We can conclude that multi-disciplinary education in entrepreneurship, integrating projects and training sessions, is effective and favors the acquisition of entrepreneurial competences and increases the interest in transformative thinking and behavior.