Smartphones and computer-based technology have revolutionized different development sectors including education. The current review describes the existing literature on Web-Based Learning (WBL) as a novel methodology applied in teaching and learning, and its potential effectiveness in teaching and learning chemistry. Further, the study intends to reflect on how the WBL could be applied in the Rwandan context of teaching and learning chemistry as the country adopted the competency-based curriculum (CBC) in 2015. This review is a narrative overview in which much of the existing literature such as books, articles, and other online literatures related to the study were reviewed. The literature was obtained from different electronic databases including Scopus, ERIC, ISI web of knowledge, academia, web of science, digital library, and google scholar.