In the context of constructing regional education and talent hub, Macao's higher education talent development strategy impacts the creation of a regional talent hub and the process of industrial diversification. This study adopts a text analysis approach. Through the analysis of 118 texts and the construction of the game model, it reveals that Macao's talent development has been passing through a "market-controlled" and "policy-driven" stage due to the uniqueness of economic and social development. The model of cooperative game based on endosymbiosis implicates that the talent attraction strategy of higher education can play a leading role in socio-economic development to form a cooperative and symbiotic equilibrium with the region as a whole through the "climbing period" when the "actual state" catches up with the "expected value." This paper proposes some policy recommendations, including: prospective discipline layout, breaking down of institutional barriers, cooperation and exchange of talent cultivation, and the creation of a talent-sharing mechanism for promoting the construction of a regional talent hub.