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ERIC Number: EJ1376297
Record Type: Journal
Publication Date: 2023-May
Pages: 11
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1759-2879
EISSN: EISSN-1759-2887
RIMeta: An R Shiny Tool for Estimating the Reference Interval from a Meta-Analysis
Jiang, Ziren; Cao, Wenhao; Chu, Haitao; Bazerbachi, Fateh; Siegel, Lianne
Research Synthesis Methods, v14 n3 p468-478 May 2023
A reference interval, or an interval in which a prespecified proportion of measurements from a healthy population are expected to fall, is used to determine whether a person's measurement is typical of a healthy individual. For a specific biomarker, multiple published studies may provide data collected from healthy participants. A reference interval estimated by combining the data across these studies is typically more generalizable than a reference interval based on a single study. Methods for estimating reference intervals from random effects meta-analysis and fixed-effects meta-analysis have been recently proposed and implemented using R software. We present an R Shiny tool, RIMeta, implementing these methods, which allows users not proficient in R to estimate a reference interval from a meta-analysis using aggregate data (mean, standard deviation, and sample size) from each study. RIMeta (https://cers.shinyapps.io/RIMeta/) provides users a convenient way to estimate a reference interval from a meta-analysis and to generate the reference interval plot to visualize the results. The use of this web-based R Shiny tool does not require the installation of R or any background knowledge of programming. We explain all functions of the R Shiny tool and illustrate how to use it with a real data example.
Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://bibliotheek.ehb.be:2191/en-us
Publication Type: Journal Articles; Information Analyses
Education Level: N/A
Audience: N/A
Language: English
Sponsor: National Library of Medicine (DHHS/NIH)
Authoring Institution: N/A
Grant or Contract Numbers: R01LM012982