This paper explores the concept of adaptive research design, in which topic, theoretical framing, method, and data are "in principle" open to adaptation during the research process. The main premise is that adaptations in one element of the research process can trigger changes in other elements. Both positive and negative reasons for adaptivity are discussed along with various valid reasons for limiting adaptivity in particular cases. Grasping the different couplings between concepts, theories and methods is useful to discern the possibilities and limits of adaptive methodology "in situ." To deepen the understanding of the adaptive capacity of methodology, we broaden the discussion to look at the embedding of methodology in academia and its disciplines. In our perspective, methods appear as devices structuring thinking and observation and are well used and placed if they enhance and enable the continuation of observation and reflection and if they allow the researcher to remain open for alternative observations and interpretations.