This study aims to investigate the relationships between spirituality, psychological well-being, compassion, and life satisfaction among adults, as well as the mediating role of compassion and life satisfaction in the relationship between spirituality and psychological well-being among adults. Using the relational survey model, 418 adults were recruited to participate in the study. The Spirituality Scale, Psychological Well-Being Scale, Compassion Scale, and Life Satisfaction Scale were used to collect data. Pearson Product-Moment Analysis was used to examine the links between adults' spirituality, psychological well-being, compassion, and life satisfaction. Using the Regression-Based Bootstrapping Technique and Serial Multiple Mediator Variable analysis, the researchers investigated the mediating function of compassion and life satisfaction in the link between spirituality and the psychological well-being of adults. The sequential mediation function of compassion and life pleasure was found to be significant in the link between adult spirituality and psychological well-being.