Teaching statistics to generalist students oriented toward a profession, rather than academic merits, may be challenging. As statistics courses also tend to have a low student appeal, tailoring a course toward this type of audience is demanding. Framed within the theory of statistical thinking and literacy, this article shows how an investigative process, using domain data and real-life examples, may facilitate meaningful learning and motivate students. Describing and reflecting upon the methods used, both in teaching and assessment, the article contributes to the practice of teaching statistics.