MegaSoTL projects are scholarship of teaching and learning (SoTL) projects that generate evidence of learning from multiple institutions. While being increasingly practiced, MegaSoTL projects and their potential contribution to improve higher education pedagogy remain understudied in higher education literature. In this article, we introduce Transparency in Learning and Teaching in Higher Education (TILT) and ManyClasses projects as two MegaSoTL case studies, and we describe their research goals, processes, and administration. We then discuss the potentials and challenges of MegaSoTL projects for educational developers to promote SoTL at micro and mega levels. The article concludes with recommendations to develop a collaborative infrastructure for supporting MegaSoTL projects.