Nearly 4 million adolescents in the United States experience clinical depression, and this alarming rate has increased in recent years. Adolescents' perceptions of their school's climate may moderate the association between victimization and depressive symptoms, including suicidality; however, it is unclear whether perceived school climate would act as a buffer or intensifier of the association between victimization and depressive symptoms. The present study examined how different types of victimization (traditional, cyber, and homophobic) are associated with depressive symptoms in middle schoolers (N = 1,151), and whether these associations are buffered or exacerbated by how adolescents perceive school climate. Multiple moderated regression analyses revealed traditional and cyber victimization were significantly positively associated with depressive symptoms, whereas homophobic victimization was not directly associated with depressive symptoms. Further, perceived school climate moderated these associations, exacerbating the link between cyber victimization and depressive symptoms, and buffering the link between homophobic victimization and depression. Results support the importance of middle schoolers' perceptions of school climate in understanding the associations between victimization experiences and depressive symptoms.