The current study examined the relationship between personality traits, social support perceptions, academic self-efficacy and the adjustment to university. Participants were 992 university students (615 [62%] female, 377 [38%]) male. Results showed that social support, conscientiousness, extraversion and at low levels agreeableness predicted friendship adjustment, while academic self-efficacy and conscientiousness predicted academic adjustment. Academic self-efficacy, social support, conscientiousness, agreeableness, and openness traits were determined to affect prediction of general adjustment to university. The significance and limitations of the results are discussed.