The current study examines intrapersonal characteristics or factors (i.e., resilience), peer (i.e., quality of peer relationships), and family processes (i.e., parental involvement, critical comparison) as potential risk and protective factors for mental health of Chinese adolescents during COVID- 19 pandemic. A total of 504 seventh-grade students (52% boys) and their caregivers in Beijing, China completed an online survey in September 2020. Youth reported experiencing various COVID-19-related stressful life events (i.e., conflicts with parents, poor learning environment and efficiency, family financial pressure), and about 15% reported slightly elevated scores of mental health difficulties. Findings suggested personal resilience and quality of peer relationship predicted positive mental health (i.e., covitality or co-occurrence of positive psychological dispositions) and less mental health difficulties. Parent's critical comparison intensified the negative link between stressful life events and youth mental health. Implications for promoting youth mental health as schools reopen are discussed.