The study explored menstrual challenges that female adolescents encountered while in school. The sequential explanatory mixed-method design was used, and both quantitative and qualitative methods were employed in analyzing the data. The study revealed that the girls were predisposed to intense and varied menstrual-related challenges, which affected quality education as they had difficulty concentrating in class coupled with social and emotional problems. The Guidance and Counseling Units in schools' continuous organization of programs to sensitize and enlighten girls on how to manage menstrual-related challenges would help to avoid the shackles the monthly experience brings.