This paper examines patterns of knowledge production in the social sciences (SS) and in the arts and humanities (A&H) in Latin America (LATAM). We report on a longitudinal analysis of 127,515 journal articles published between 2002 and 2018. The analysis reveals six major patterns: (i) a rapid growth in the production of journal articles; (ii) large differences in article production across nations; (iii) significant variations in the magnitude and the growth of articles across disciplines within the SS and the A&H; (iv) a present predominance of single-authored articles that has nevertheless been declining in favour of collaborative articles; (v) a significant variation in the magnitudes of collaborative articles with researchers outside LATAM, a collaboration that tends to be with the global North; and (vi) differences in research leadership across LATAM nations. A set of possible explanations is offered for each of these patterns, set within a dynamic global knowledge production context.