The interactions that Students of Color have in college have been shown to influence numerous outcomes. Previous research has not proposed and validated a model for student success with this population that concurrently measures multiple types of interactions with multiple constituents. The purpose of this study was to assess how academic, social, and deeper life interactions with peers, faculty, and staff influence thriving for Students of Color. Employing a quantitative approach, we used survey data from 279 undergraduate students at large research universities to analyze the relationships among interaction and thriving variables. By confirming a predictive structural model, we established the value of using student interactions to further understand the experiences of Students of Color and to explore what leads to different factors of success in their academic, interpersonal, and intrapersonal domains. Implications for practice and future research are also discussed.