The curiosity to determine the mechanisms for development of innovative skills in learners and the efficacy of innovative pedagogies in improving students' achievement in Taxation and acquisition of 21st-century skills is what informed this research. We assigned 248 taxation students to three classes, two taught with innovative methods. Results showed that students who received treatment had significant improvements in academic achievement and developed 21st-century skills more than those in the control groups. We recommended that government, educational institutions and other stakeholders should enact and implement policies on integrating innovative pedagogies and 21st-century learning models into taxation curricula. The implications and limitations of the study were also discussed.