The paper focuses on the topic of e-tutoring within the context of Higher Education. The research target is a framework for e-tutor role and skills in a higher education environment. The research began with a systematic review of the scientific literature with the aim of having a vision on the scientific landscape about the approach of universities to online tutoring and on the role and skills of tutors. Subsequently, to investigate more in depth, the research had a second phase with the use of a questionnaire divided into five sections, administered to two different figures of and tutors (disciplinary tutors and online tutors) of eCampus, in one of the online Italian universities. The discussion on the results investigates how important e-tutoring is for students' online learning, especially as regards the pedagogical, organization and pastoral dimensions.