University students crave immersive, collaborative, interdisciplinary, applied learning contextualized to real world sustainability challenges. Liberal arts and sciences institutions are particularly well positioned to respond. Here we report on our high impact, cross-disciplinary, biomimicry-themed firstyear experience (FYE) curricula. Biomimicry is an emerging, multidisciplinary approach to innovative problem-solving that seeks to emulate functional biological adaptations to inspire more innovative, efficient, resilient, and regenerative solutions to human challenges. In the classroom, biomimicry fosters higher-order thinking, creativity, and imaginative problem-solving while teaching the fundamentals of functional biology, STEM research, communication, and systems thinking. The highly integrative, skills-focused, experience-based, and philosophy-grounded nature of our curricula is optimized for the liberal arts and sciences FYE mission. Our goal is for students to successfully begin their transition to the liberal arts and sciences undergraduate setting, relate more strongly to the natural world, and draw inspiration for human problem-solving from nature. Merging the first-year seminar and biomimicry pedagogies seems to amplify learning in both areas. We share highlights of our curricula and pedagogy to encourage the development of more nature-based biomimicry first-year seminars promoting global citizenship at other liberal arts and sciences institutions.