With the development of inclusive higher education, an increasing number of students with hearing impairment have gained access to university. However, evidence obtained from both international studies and studies in China, by and large indicates that students with hearing impairment are confronted with difficulties in academic domains, social domains, and facilities and services in their university life. This study aims to address this issue by exploring how university self-efficacy relates to quality of university life among university students with 15 hearing impairment and hearing students in mainland China. A demographic sheet, the University Self-efficacy Scale, and the Quality of University Life Measure (QULM) administered to 350 students with hearing impairment and 463 hearing students. Multiple regression analyses were performed separately for each of the quality of university 20 life scales, with all university self-efficacy scales serving as predictor variables in each analysis, and with relevant demographic variables being controlled for. Results showed university self-efficacy significantly and positively predicted quality of university life among all the participants. The limitations, contributions, and implications of the present research are discussed.