On basis of Synergistic Leadership (Irby et al., 2002), Situational Leadership (Hersey & Blanchard, 2008), the support systems in Framework for 21st Century Learning (P21, 2019), and related research, this research employed questionnaire surveys and interviews in four application-oriented universities (AOUs) in Shanghai, characterized by disciplines of humanities, arts, technology, and health. Findings from questionnaire surveys and interviews showed that: 1) 45 leadership factors in the context of AOUs in Shanghai may be synthesized from dimensions of stakeholders' perceptions, leadership behaviors, and external forces; and 2) leadership styles may start at any point of directing to coaching styles, and gradually transform to supporting, and specific leadership behaviors have been provided to CE instructors or instructional leaders in determining or adapting situational leadership styles to learners' situation in AOUs in Shanghai. Based on the findings, the model "Leadership Atomium" was developed for instructional leaders and instructors to support learners' mastering CE core competencies for their better preparations for future life and work.