Secondary career and technical education (CTE) provides high school students the opportunity to gain occupational skills for in-demand 21st century jobs linked to college and career readiness (CCR). All students, including those with a disability, can benefit from CTE. Secondary CTE is a predictor of positive post-school outcomes for students with disabilities (SWD; Mazzotti et al., 2021). This study explored the Perkins Collaborative Research Network (PCRN) data associated with secondary CTE and SWD participation from school years 2014-2015 to 2018-2019 to establish a baseline in enrollment. The data provides a point of reference and trends to better understand serving SWD in CTE and sheds light on access, equity, and inclusion framed in policy and practice articulated by Harvey et al. (2020). The findings can also inform continued work associated with a CCR framework for SWD (Morningstar et al., 2017).