Academic misconduct has been conceptualized as students' engagement in various types of proscribed behaviors, such as plagiarism and cheating on assignments and tests or exams (e.g., Stephens et al., 2021). While most of the current literature on academic misconduct has focused on developed countries, the problem is rampant across the world (Krou et al., 2021), especially in developing countries (e.g., Gaytán & Quintanilla-Domínguez, 2014; Stephens et al., 2010). Gaytán and Quintanilla-Domínguez (2014), for example, found that the rate of academic misconduct in Mexican universities was significantly higher than the estimated rate in the United States. More recently, Guerrero-Dib et al. (2020) found that students who reported engaging in academic misconduct were more likely to be dishonest in non-academic contexts. Surprisingly, despite the extent of academic misconduct and its association with other forms of dishonesty, little else is known about the problem in Mexico. In order to help fill this void, the present study examined the relationship between life-purpose orientations and academic misconduct among university students in Mexico.