The article describes a science activity designed to increase students' knowledge and awareness of the spread of COVID-19. It helps students achieve scientific literacy through improving their views about the nature of science and their argumentation skills. It also promotes students' engagement in scientific practices such as modelling, collecting data, analysing it, and representing it in tables and graphs. The activity aims to simulate the spread of any infectious disease. It adopts the 5E approach, which is integrated into the context of inquiry, argumentation and nature of science. Integration of science and mathematics is also an added value of the activity.