Sexual and gender minority (SGM) youth experience higher rates of adverse mental health outcomes, most notably suicidal thoughts and behaviors (STBs). The current study examines risk and protective factors for STBs and depression among 1,078 youth in high schools. We examine these outcomes through an intersectional lens, and we extend the use of the minority stress theory framework by focusing on resilience and protective factors and argue that bias against lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth should be addressed at the systemic, rather than the individual, level. Our findings suggest that family support is a notable factor protective of depression and suicide-related behavior among LGBTQ youth. Additionally, peer support, help-seeking beliefs, access to medical and counseling services, engaging in healthy activities, spirituality, and having trusted adults are protective factors for some groups. The nuanced findings in this study offer suggestions for school psychologists and professionals to promote healthy and safe school environments.