Purpose: This paper argues that large-scale agricultural programmes embedded with the Agricultural Innovations Systems (AIS) thinking helps in facilitating innovations. Design/Methodology/Approach: The study adopted a qualitative approach involving focus group discussions, key informant interviews and secondary document analysis. This approach helped to obtain an in-depth understanding of the processes involved, why and how innovation takes place. Findings: The design and implementation of the MiDA programme had elements of the AIS embedded. This helped to contribute to success in areas that aligned and failures in areas that fell short. Stakeholders encountered implementation challenges that did not ensure reflective learning, conversely, some actors worked independently of others, mimicking linear extension approaches. Practical Implications: The future of extension and research in Ghana should not be prescriptive (top-down) but fully integrate farmers and wider stakeholders in the design and implementation of agricultural investment programmes. This is premised on addressing challenges relating to trust, effective leadership and entrepreneurship. Theoretical Implications: Adds on to the limited use of AIS as a conceptual and operational tool in supporting large-scale agricultural investment in the global south by incorporating AIS thinking in policy formulation and implementation of large-scale programmes. Originality/Value: This article adds to the unbalanced literature in Sub-Saharan Africa on the use of AIS in the design and implementation of large-scale programmes. Additionally, it highlights the use of AIS in extension and research in facilitating innovations.