The overturning of "Roe v. Wade" and the increasing assaults on lesbian, gay, bisexual, transgender, queer (LGBTQ+) rights in legislatures across the country have put our sexual and reproductive health in peril. They are likely also bellwethers of more to come. While a full reckoning of the repercussions from these attacks will not be known for a long time, the field of public health must act now with a strong and cohesive plan to mitigate the harms, fight these threats to our well-being, and lead the way forward.