This article focuses on the impact of COVID-19 on Latinx undergraduate students persistence to medical school. Guided by Chicana/Latina Feminist Epistemology (Fierros & Delgado Bernal, 2016) and cultural assets from Latinx STEM Student Success Model (Rendón et al., 2019) this paper aims to take on an asset-based approach and center the voices and experiences of Latinx students in premedical studies as they persist towards medicine during a national pandemic. This study engaged 24 Latinx undergraduates during the summer of 2020, the height of the pandemic. Findings reveal the following themes on impact of COVID-19, (1) Navigating delays in medical school application timelines, (2) Navigating multiple stressors from home to health, (3) Navigating the online shift of clinical and volunteer experiences and (4) Motivations to address Latinx health disparities. Findings suggests Latinx students persisted in the face of a global pandemic and made connections to the larger structural issues that impact Latinx health outcomes.