School delinquency in public elementary, middle, and high schools has decreased in recent years, but is still a major issue that has negative mental health and academic implications for adolescents. Although research has focused on both individual-level and school-level explanations of school delinquency, it is not yet clear which macro-level criminological perspectives best explains it. Using 656 effect sizes nested within 75 studies and 30 unique datasets, this study addresses two questions using meta-analytic methods: Which macro-level criminological perspectives explain between-school differences in delinquency? Are effect sizes invariant across samples and research design? Results indicate that only concentrated disadvantage and social cohesion are significantly related to school delinquency. With the exception of concentrated disadvantage, effects are homogenous. This suggests that some school-level explanations are useful and future research should not exclude these factors. Practical implications suggest that improving social cohesion in schools may be more effective at preventing violence than target-hardening efforts.