A trauma-informed organization serving young children and their families experienced differentials in vaccine uptake. Organization leadership viewed this response through a trauma-informed framework that recognizes legacies of scientific racism and attendant distrust of medical information, particularly new treatments. Trauma-informed frameworks require sensitive organizational responses to address issues of vaccine hesitancy, as organizations set policies to balance the risks of re-traumatization with the risks to everyone's physical health. This agency considered it an ethical imperative to support efforts to increase vaccination rates to protect clients and staff from COVID-19 infection as part of its official charge, while also balancing the experiential reality that many minoritized and marginalized communities face in reference to mistrust of U.S. health care policies.