The COVID-19 pandemic provides an opportunity for teachers to explicitly address nature of science (NOS) themes during instruction. Aligned with key NOS categories in the "Next Generation Science Standards," this article discusses events and trends from the pandemic that teachers can use to help students understand values and methods of science, including what science is and how it works. Examples from the pandemic (with NOS topics) include development of multiple vaccines (science investigations using a variety of methods based on a common set of values, science is a human endeavor, the relationship between science and technology); revising recommendations on mask use and quarantine protocol (scientific knowledge being open to revision in light of new evidence); and the relationships among science and other social contexts (science as a way of knowing, addressing questions about the natural world).