This concept paper aims to introduce academic entrepreneurship as a subject of particular significance in the CALL field in the knowledge economy era. The article describes why the primary CALL practitioners--faculty and students--should invest their time, skills, and resources to pursue, identify, and exploit entrepreneurial opportunities and create far-reaching technological products and services for language instruction and research. The paper advocates for creating a particular research area in which CALL researchers and academic entrepreneurs will showcase their practical uniqueness and experience in CALL academic entrepreneurship to motivate and inspire one another. The paper also advocates for the inclusion of entrepreneurship education into the CALL preparation curriculum to produce graduates with the entrepreneurial skillset that will enable them to be active participants in identifying and exploiting CALL-related entrepreneurial opportunities.