The pandemic of COVID-19 has changed the learning process, from face to face and blended and fully e-learning facilitated by electronic media that can be reached by lecturers and students. They are required to use e-learning so they can do learning process from home or anywhere due to the physical and social distancing imposed by the government. This study examined the quality of e-learning, student's self-efficacy, and satisfaction in using e-learning. It involved 345 students from Management Study Program in Universitas Muhammadiyah Sumatera Utara and the data collection was carried out by distributing questionnaires. The regression analysis was conducted to examine the effect of self efficacy and e-learning quality toward e-learning users' satisfaction. The results showed that there was an effect of self efficacy and e-learning quality toward e-learning users' satisfaction where the theoretical and institutional implications for e-learning in higher education discussed.