The present study examines the potential protective effect of familial support among first-gen Mexican descent college students regarding GPA, college persistence, and depressive symptoms. Participants included 487 Mexican descent college students from across the United States (66.7% first-gen). Results indicated that being a first-gen student was not related to the outcomes; however, family support was related to better academic and psychological outcomes (lower depressive symptoms and higher college persistence) regardless of generation status.