The aims of this mixed-methods study were (a) to explore quantitatively the fit of the COPE inventory (Coping Orientation to Problems Experienced) for Latinx youth from immigrant families, and (b) to explore qualitatively aspects of coping in this population. Participants were 175 Latinx adolescents (51% female), most of whom were U.S.-born with immigrant parents (88%) and primarily of Mexican origin (89%). The average age was 12.9 years for the quantitative study and 15.7 years for the qualitative study. Qualitative interviews engaged a subset (n = 14) of the full study. All participants lived in the southeastern United States and the research received institutional review board (IRB) approval. The confirmatory factor analysis of the COPE inventory was not a good fit for the sample. Thus, an exploration of alternative approaches to coping was undertaken (exploratory factor analysis [EFA] and qualitative interviews). A three-factor solution was selected as the best fit in the EFA; the researchers labeled the factors as "purposeful cognitive/behavioral engagement," "support seeking," and "separation/disengagement." In the qualitative interview data, five main themes were described (relational coping, positive thinking/self-talk, planning, separating/disengaging, and behavioral coping). The researchers suggest implications for reframing coping with Latinx participants or collectivist groups, emphasizing the central role of cultural values.