Introduction: Burnout emerges as a common problem during the university period when social competition and expectations from the individual increase, and daily life becomes increasingly complicated due to augmenting stress factors. The aim of this study was to examine whether the school burnout of university students can be predicted significantly by adjustment to school. Methods: This study used a correlational survey model to investigate the burnout levels of university students in terms of their adjustment to university life. The sample of the study comprised a total of 334 students, enrolled in four different faculties of a university in Turkey. The data of this research were collected by using the "Adjustment to University Life Scale (AULS)", "The Maslach Burnout Inventory-Student Form (MBI-SF)" and personal information form. Results: The findings obtained in this study showed that academic, social, and personal adjustment to university life among university students negatively and significantly correlated with school burnout that students experienced. In addition, personal, social and academic adjustment variables together significantly predict each of the exhaustion, cynicism and efficacy variables. Discussion: According to these results, academic, social, and personal adjustment to university life among university students negatively and significantly correlated with school burnout that students experienced. This situation indicates that as students' academic, social, and personal adaptation to university life increases, they will experience less emotional burnout, become less cynical of their environment, and feel less personal inefficacy. In this context, it is thought that interventions that support adaptation to university life are an important factor that will protect students from the negative effects of burnout. Limitations: The sample of this study is limited to 334 participants. In addition, the findings of the study are limited to the sincere response of the participants to the instruments of the study and the qualifications of the measurement tools. In other words, this research has no claim of generalizability. Conclusions: According to the findings of the study, students with high adjustment to university life experience less academic burnout. In this context, both individual and group work to be conducted by the guidance and psychological counseling units of universities gain importance. It will be particularly beneficial to conduct studies for adjustment to university life, such as psycho-education, group psychological counseling, or peer guidance.