Given the importance of career discernment in emerging adulthood, we evaluated an understudied career development approach for higher education students. Specifically, we tested the relationship between spiritual discernment exercises and sense of purpose and calling through the indirect effects of self-concept clarity, career decision self-efficacy, and knowledge of occupational information. Participants (N = 127) were randomly assigned to one of the three conditions and were surveyed at a 10-week interval. Results indicated significantly higher posttest scores for purpose (B = 0.169, p = 0.026) and calling (B = 0.134, p = 0.013) in the spiritual discernment condition compared to the general adjustment (i.e., control) and traditional career development conditions. Mediation analyses also revealed a significant indirect effect of self-concept clarity on sense of purpose (B[subscript ab] = 0.059, p = 0.033). These findings suggest that spiritual discernment practices can significantly enhance the effectiveness of career development interventions for discerning purpose and calling.