This study explores the use of blockchain in the course design and evaluation in Chinese universities, and explores the value of teachers' views and experiences on blockchain in the course design. Previous studies have shown that blockchain has a positive effect on the improvement of online teaching management and evaluation quality. Most of the current research focuses on the management of online teaching by using blockchain, and this qualitative case study investigates the design and evaluation of online course based on blockchain by five teachers of different specialties. Semi-structured interviews and course materials were collected from five teachers for a TPACK framework analysis. The result of the survey emphasizes that the redesign of online courses based on blockchain can improve the matching between blockchain and courses, the quality of teaching and the trust of various parties in online education. The blockchain-based the online course of both theory and practice design and evaluation, which is oriented by the index method of capability evaluation, is an appropriate idea and has achieved good results. The experimental course focuses on the integration of blockchain and experimental platform. The immersive and interactive course presentation and the personalized examination based on machine learning are effective. But follow-up should pay attention to the different requirements of course design of different disciplines, using a variety of data sources for analysis, to take measures to enhance the enthusiasm of teachers to adopt new technologies.