Sensation-seeking, subjective vitality and happiness are interrelated constructs in the current literature. However, there is currently no research on how the relationship between these concepts is affected. This research aims to examine the mediating effect of resilience in the relationship between them, thus bridging a large gap in the field. The group of participants in the research consisted of 519 university students; 384 (74%) of them women and 135 (26%) of them men. In addition, the average age of the participants was 20.17 (Sd = 1.36). We used sensation seeking, resilience, subjective vitality and Oxford happiness scales in the research. We used mediation analysis to determine the indirect effect of resilience between sensation seeking and subjective vitality and happiness. The results revealed a minor, positively significant relationship between sensation seeking and resilience, subjective vitality, and happiness, indicating that resilience plays a mediating role in the relationship between the concepts of. Moreover, a high level of psychological resilience increases subjective vitality and happiness. Based on these findings, guidance and psychological counselors in schools may be able to better guide improving students' mood.