Accounts of educational opportunity gaps for Black boys are overwhelmingly focused on later years of development. Achievement and discipline disparities are evident across their lifespan. Life course and intersectionality theories were used to develop a framework for understanding obstacles Black boys face during their preschool through high school years. Outlining the cumulative impact of threats and protective factors for their academic success provides insight for supporting Black boys at various developmental stages. Implications include tools for families, educators, and practitioners. This perspective will enhance the collective understanding of the resiliency of Black boys and support their educational success throughout the life course.