Purpose: The purpose of this study was to examine whether functional limitations mediate the relation between PTSD symptoms and college life adjustment in student veterans with PTSD symptoms. Methods: A total of 232 student veterans with PTSD symptoms were recruited for this study. Participants were predominantly male (84.5%; females = 15.5%). Participants' ages ranged from 18 to 54 years (M = 28.43, SD = 5.42). Correlational analyses were conducted to calculate the relationships among study variables. We also conducted a mediation analysis to examine whether functional limitations mediate the relationship between PTSD symptoms and college life adjustment. Results: The mediation analysis indicated that the effect of PTSD symptoms on college adjustment can be partially explained by functional limitations. Conclusion: Our results have potentially important implications for rehabilitation counseling researchers and clinicians in the COVID-19 era.