The purpose of the study was to determine E-learning in the development of ICT in the field of education at private universities under the auspices of Nadhatul Ulama Indonesia. The research is located at two well-known private Islamic universities, namely the Islamic University of Malang (UNISMA) and Nadhatul Ulama University Surabaya (UNUSA). The methodology used is qualitative research by exploring and understanding the role of e-learning and ICT development in the university. Sources of data come from observations and interviews with academics from two research locations written in field notes and relevant documents. Qualitative data analysis was carried out by conducting data reduction in the form of abstractions, arranging them in units which were then categorized while coding and checking the validity of the data. The results of the study after exploring the two best Nahdatul Ulama universities (PTNU), it turns out that UNISMA is better prepared as a pilot project leader for PTNU E-learning in Indonesian and international university networks in the future. Meanwhile, UNUSA continues to struggle to persuade teachers and students to engage in regular E-learning. Also, there is a lack of executive support for making flexibility in the teaching and learning process relevant to E-learning deployment. These findings suggest that the role of e-learning in Islamic universities under the leadership of Nadhatul Ulama Indonesia is still hampered by a number of challenging issues. Interestingly, the problem of internet data connection constraints is not found in the two Nadhatul Ualam Islamic Colleges which are generally found on other campuses, the main obstacle is the lack of support from human resources and decision-makers in terms of management support. The expected implication is for universities to evaluate and improve in terms of technology management. In addition, the Government supports facilities and policies in enhancing the development of ICT with more modern features in the future.