This chapter describes specific examples of the implementation of TSPACK framework in Foundry-guided contexts using a case study approach, featuring applications in both regional and international contexts. As education shifts toward active learning, discovery processes, and collaboration across disciplines, a space that fosters the facilitation of such interaction is invaluable. The TSPACK framework paired with the Renaissance Foundry Model elevates space as an essential element for the exchange of ideas that fosters equitable opportunities for new knowledge construction.