This study investigates the independent level of entrepreneurial interest between male and female business college university students in Dammam, Saudi Arabia, and the factors influencing their entrepreneurial interests from the gender perspective. The Chi-square result revealed there is no statistical difference between male and female students, thus signifying that they are both equally interested in starting their own business. The results of logistic regression indicated that attitude towards behaviour, entrepreneurship education, self-efficacy, government support, university context and risk-taking have greater likelihood to influence entrepreneurial interests of female and male students, since their odd-ratios are greater than 1. More so, attitude towards behaviour, self-efficacy, government support, university context, relational support and risk-taking are statistically significant in influencing females' entrepreneurial interests. Meanwhile attitude towards behaviour, entrepreneurship education, self-efficacy and university context are significant in influencing males' entrepreneurial interests. Hence, governmental, relational and university supports should be fostered to improve students' entrepreneurial interests.