Science centers provide an engaging way for young learners to explore related concepts. The hands-on nature of each exercise secures the stimulation necessary to maintain focused attention. In this article, the authors describe a multi-day 5E (Engage, Explore, Explain, Elaborate, Evaluate) lesson on nocturnal and diurnal animals with science centers embedded as the Explore portion. This child-centered approach was selected since it engrossed the authors' young students in meaningful learning. The lesson was taught with a Montessori-based multiple-age classroom of three- to six-year-old learners. This lesson is aligned to: K-LS1-1. Use observations to describe patterns of what plants and animals (including humans) need to survive. Students were introduced to patterns and structure and function while looking for adaptations that help nocturnal animals survive including: excellent eyesight, good sense of smell, good sense of hearing, specialized hairs, and echolocation. Though science centers were themed around nocturnal animals, the method transcends this topic. This 5E lesson is an excellent way to have young learners engage with hands-on science.