With increased tensions and political rhetoric surrounding immigration enforcement in the United States, schools are facing greater challenges in ensuring support for their students of immigrant and Latinx origin. This study examined the associations between county-level immigration arrests and academic achievement, absenteeism, and measures of school climate and safety for students in the California CORE districts. Using ordinary least squares regression analyses with year, grade, school, and student fixed effects, we found that immigration arrests corresponded to declines in academic achievement, attendance, and various measures of school climate and safety for Latinx students and Latinx students who were English learners. We also find small declines in measures of school climate and safety for students who ever received special education services via an Individualized Education Program. Associations were strongest for arrests that occurred during the Trump administration compared with those that occurred during the second term of the Obama administration. Policy implications are discussed.