With the continuous development of technology and people's dependence on the Internet, more and more teachers' professional development is carried out on the Internet. Since no one has studied the professional development of online middle school teachers, we did this study based on this research gap. This article is a research on the professional development of chemistry teachers based on the Internet. It uses content analysis methods to identify research questions and select keywords related to the topic, such as online teacher professional development, chemistry teacher professional development, secondary school teacher professional development and so on and codes the data. From this, we found that the strategies for the professional development of online teachers in middle school chemistry subjects includes chemical content, practice, guidance, exploratory experiment, online communication community, self-reflection, sustainability, continuity and action these eight parts. And online chemical TPD for student outcomes in middle school contains: gain knowledge, skills and confidence, determined their goals and plans, participate in scientific inquiry teaching and improve student performance, promote the transformation of students' scientific knowledge concepts, and have a positive influence on students' attitudes towards science.