Purpose: This study focused on cross-region student mobility to explore whether Macao students have adjustment issues while studying and living in Taiwan. Design/Approach/Methods: A total of 663 Macao students were surveyed in Taiwan, and the statistical methods, including correlation, "t"-test, analysis of variance, and hierarchical regression analysis were addressed to analyze the data. Findings: Macao students, even while studying in a Chinese context, did have social and psychological adjustment issues (i.e., social support and self-efficacy). Originality/Value: This study could shed some light on understanding cross-region students as well as providing practical guides for relevant governmental departments in their policy regarding outbound students.